Season
- Season 21 2013-01-02
- Season 20 2012-01-03
- Season 19 2011-01-03
- Season 18 2010-03-01
- Season 17 2008-06-02
- Season 16 2007-09-17
- Season 15 2006-09-18
- Season 14 2005-06-06
- Season 13 2004-06-07
- Season 12 2003-06-02
- Season 11 2002-06-03
- Season 10 2002-04-30
- Season 9 2000-08-01
- Season 8 1999-07-30
- Season 7 1998-02-26
- Season 6 1997-12-05
- Season 5 1996-09-16
- Season 4 1996-03-07
- Season 3 1994-11-28
- Season 2 1993-06-25
- Season 1 1992-05-25
- Season 0 2014-02-06
Episode
- Episode 1: Jason Lee, Elton John
- Episode 2: Justin Timberlake, Sarah Silverman
- Episode 3: Steve Carell, Jamie Lee Curtis, Joan Jett
- Episode 4: Teri Hatcher, Jon Heder, Kenny Chesney
- Episode 5: Calista Flockhart, Harland Williams, Gomez
- Episode 6: Eva Longoria, Cole and Dylan Sprouse, Death Cab for Cutie
- Episode 7: Adrien Brody, Chef G. Garvin, Alan Jackson
- Episode 8: Evangeline Lilly, Magic Johnson, Diana Krall
- Episode 9: Ashton Kutcher, Jenna Fischer, Amos Lee
- Episode 10: Jessica Simpson, Bill O'Reilly, Snow Patrol
- Episode 11: Wanda Sykes, Chris Matthews, John Mayer
- Episode 12: Helen Mirren, B.J. Novak, Jet
- Episode 13: Michael Clarke Duncan, Lisa Lampanelli, Rod Stewart
- Episode 14: Bob Newhart, Kristin Chenoweth, Camp Freddy
- Episode 15: Jarod Miller, Bradley Whitford, Ray LaMontagne
- Episode 16: Tina Fey, Annika Sorenstam, Fergie
- Episode 17: Tiger Woods, Emeril Lagasse, Chingy
- Episode 18: Arnold Schwarzenegger, Heidi Klum, Le Rêve
- Episode 19: Sandra Bullock, Michael Caine, Chris Young
- Episode 20: David Gregory, Ali Larter, Edie Brickell & The New Bohemians
- Episode 21: Hugh Jackman, Tim McGraw
- Episode 22: Jennifer Love Hewitt, Tim Burton, Barry Manilow
- Episode 23: Annette Bening, Mad Scientist David Willey, Sarah McLachlan
- Episode 24: Sally Field, Bug Man Ruud Kleinpaste, Kevin Federline
- Episode 25: John Landis & The Spiridellis Brothers, JoJo
- Episode 26: Tim Allen, 8-year-old opera singer Gwyn Mackenzie, Carrie Underwood
- Episode 27: Roseanne Barr, Sharon Osbourne, Marilyn Manson
- Episode 28: Emma Thompson, Spencer Breslin, Regina Spektor
- Episode 29: Penelope Cruz, John Stamos, "Weird Al" Yankovic
- Episode 30: Russell Crowe, Rachael Ray, Kellie Pickler
- Episode 31: Hugh Laurie, America Ferrara, the Cheetah Girls
- Episode 32: Courtney Love, Brad Garrett, OK Go
- Episode 33: Ellen DeGeneres, Fred Willard, Tony Bennett
- Episode 34: Borat, Martha Stewart, Damian Rice
- Episode 35: Lindsay Lohan, Emmitt Smith, Army Of Anyone
- Episode 36: Sharon Stone, Patricia Arquette, Vince Gill
- Episode 37: Rachel Weisz, Nick Cannon, Il Divo
- Episode 38: Jaime Pressly, Adventurer Bear Grylls, Cirque du Soleil: The Beatles - LOVE
- Episode 39: Emilio Estevez, D.L. Hughley, Josh Groban
- Episode 40: Kate Winslet, Wilmer Valderrama, Buddy Guy
- Episode 41: Demi Moore, Ron Livingston, Chris Cornell
- Episode 42: Denzel Washington, Catherine O'Hara, Jerry Lee Lewis with Kid Rock
- Episode 43: Amazing Animals With Julie Scardina, Ellen Pompeo, Nelly Furtado
- Episode 44: Howie Mandel, Nelly Furtado
- Episode 45: Kristin Davis, Ralphie May
- Episode 46: Cameron Diaz, Gwyn Mackenzie, The Wreckers
- Episode 47: Lucy Liu, Bob Saget, Snoop Dogg
- Episode 48: Al Gore, Karolina Kurkova, Fantasia
- Episode 49: Morgan Freeman, Josh Duhamel, Barenaked Ladies
- Episode 50: Sen. Barack Obama, Maggie Gyllenhaal, Taylor Hicks
- Episode 51: Cate Blanchett, Larry the Cable Guy, Corinne Bailey Rae
- Episode 52: Dennis Miller, LaDainian Tomlinson, K.T. Tunstall
- Episode 53: Jack Black, Chef G. Garvin, Paulina Rubio
- Episode 54: Mel Gibson, Bil Dwyer, Ludacris
- Episode 55: Sylvester Stallone, Parminder Nagra, Seal
- Episode 56: Former President Jimmy Carter, Edward Norton, Panic! At the Disco
- Episode 57: Jamie Foxx, Brad Paisley
- Episode 58: Dakota Fanning, Aaron Eckhart, Twisted Sister
- Episode 59: Leonardo DiCaprio, Naomi Watts, The Goo Goo Dolls
- Episode 60: Tobey Maguire, spider expert Jules Sylvester, Sarah McLachlan
- Episode 61: Samuel L. Jackson, Nick Thune, Scott Weiland
- Episode 62: Robert De Niro, Jennifer Hudson
- Episode 63: Will Smith, Pamela Anderson, Richard Roeper, The Blind Boys of Alabama
- Episode 64: Matthew McConaughey, Opie and Anthony, The Killers
- Episode 65: Dustin Hoffman, Abigail Breslin, African Children's Choir
- Episode 66: George Clooney, Maria Lark, Unwritten Law
- Episode 67: Justin Timberlake, Masi Oka, Matisyahu
- Episode 68: Hilary Swank, Tom Papa, Akon
- Episode 69: Terry Bradshaw, baker Marjorie Johnson, Papa Roach
- Episode 70: Kiefer Sutherland, Betty White, Chris Daughtry
- Episode 71: Ben Affleck, Chris Leak, Jewel
- Episode 72: Sen. John Edwards, Terri Irwin, Mindy Smith
- Episode 73: Helen Mirren, Isaac Mizrahi, Los Lonely Boys
- Episode 74: Renée Zellweger, Joy Behar, Common
- Episode 75: Paula Abdul, D.L. Hughley, Tyrese feat. Lil Jon
- Episode 76: Matt Lauer, John & Margaret Ragonese, The All-American Rejects
- Episode 77: Meredith Vieira, Ryan Reynolds, Robin Thicke
- Episode 78: James Woods, Lisa Lampanelli, Five For Fighting
- Episode 79: Don Rickles, John Stamos, Rocco DeLuca & The Burden
- Episode 80: Jennifer Garner, Ty Pennington, Bow Wow
- Episode 81: Jon Cryer, Jeff Garcia, Switchfoot
- Episode 82: Sienna Miller, Phyllis Diller, Branford Marsalis Quartet
- Episode 83: Wanda Sykes, Sendhil Ramamurthy, The Bird And The Bee
- Episode 84: Rebecca Romijn, Bob Saget, Rodrigo Y Gabriela
- Episode 85: Bill Cosby, Mary Lynn Rajskub, Katharine McPhee
- Episode 86: Diane Keaton, Ivanka Trump, The Soweto Gospel Choir
- Episode 87: Forest Whitaker, America Ferrera, Daniel Powter
- Episode 88: Abigail Breslin, Amazing Animals With Julie Scardina, Christina Aguilera
- Episode 89: Cuba Gooding Jr., Miss USA Tara Conner, The Game
- Episode 90: Clint Eastwood, Jennifer Hudson, John Waite and Alison Krauss
- Episode 91: Penelope Cruz, Tyler Perry, James Hunter
- Episode 92: Hugh Grant, Himalayan Bears With Julie Scardina, Norah Jones
- Episode 93: Mark Wahlberg, Sarah Silverman, Mat Kearney
- Episode 94: Drew Barrymore, Kyle Krichbaum, Solomon Burke
- Episode 95: Nicolas Cage, D.J. Sampson & Sam Ballerini, The Fray
- Episode 96: Dennis Miller, baker Marjorie Johnson, Taylor Swift
- Episode 97: Beyoncé, Charles Barkley, Kenny Wayne Shepherd
- Episode 98: Jim Carrey, Gov. Tom Vilsack, Dustin Kensrue
- Episode 99: Teri Hatcher, Rhys Ifans, Omarion
- Episode 100: Simon Cowell, Randy Jackson & Ryan Seacrest, Tiki Barber, Silversun Pickups
- Episode 101: Bill Maher, skydiving accident survivor Michael Holmes, Rodney Atkins
- Episode 102: Jaime Pressly, Gordon Ramsay, Gomez
- Episode 103: Peter O'Toole, Christina Ricci, Hellogoodbye
- Episode 104: Animals With Joan Embery, William H. Macy, John Mellencamp
- Episode 105: Courteney Cox, Richard Roeper, Plain White Ts
- Episode 106: John Travolta, Katt Williams, Everclear
- Episode 107: Tim Allen, Hollywood's Most Talented Animals, Fergie
- Episode 108: Howie Mandel, Chris Hansen, Korn
- Episode 109: Queen Latifah, Gerard Butler, Buckcherry
- Episode 110: Mark Wahlberg, Brad Garrett, My Chemical Romance
- Episode 111: Sandra Bullock, Andy Richter, Evanescence
- Episode 112: Minnie Driver, Bailee Madison, Finger Eleven
- Episode 113: Dan Rather, bizarre food expert Andrew Zimmern, Lloyd
- Episode 114: Terry Bradshaw, Mary Lynn Rajskub, Musiq Soulchild
- Episode 115: Terrence Howard, Bruce Fine, the cast of "Jersey Boys"
- Episode 116: David Spade, Richard Engel, Hinder
- Episode 117: Roseanne Barr, Heather Mills, James Morrison
- Episode 118: Will Ferrell, Sen. Joseph Biden, Paolo Nutini
- Episode 119: Nick Nolte, bug expert Rudd Kleinpaste, Guster
- Episode 120: Quentin Tarantino, Pete Rose, Mika
- Episode 121: Jeff Foxworthy, Charlie Engle, Kevin Lin & Ray Zahab, Dierks Bentley
- Episode 122: Hilary Swank, Carlos Mencia, Gym Class Heroes
- Episode 123: Campbell Brown, Will Arnett, Dave Koz feat. Johnny Mathis
- Episode 124: Amy Poehler, Ricky Schroder, Ozomatli
- Episode 125: Kurt Russell, Shia LaBeouf, Hilary Duff
- Episode 126: Gerard Butler, Tim McGraw
- Episode 127: Jennifer Love Hewitt, Brandi Carlile
- Episode 128: Craig T. Nelson, Molly Shannon, Sick Puppies
- Episode 129: Jeremy Piven, Jenna Fischer, John Legend
- Episode 130: Anthony Hopkins, Rose McGowan, Good Charlotte
- Episode 131: Jamie Lee Curtis, Jonathan Rhys-Meyers, Patty Griffin
- Episode 132: Wanda Sykes, Jesse James, Rickie Lee Jones
- Episode 133: Julia Louis-Dreyfus, Rep. Nancy Pelosi, Relient K
- Episode 134: Rainn Wilson, Orny Adams, The Shins
- Episode 135: Luke Wilson, Alexandra Wentworth, Lily Allen
- Episode 136: Tim Russert, Eddie Izzard, Three Days Grace
- Episode 137: Tobey Maguire, Tori Spelling, Wicked
- Episode 138: Jack Black, Sanjaya, OK Go
- Episode 139: Kevin Bacon, Hayden Panettiere, Michael Phelps
- Episode 140: Zach Braff, Pat Summitt, Joss Stone
- Episode 141: Bill Maher, Sig & Edgar Hansen, Amy Winehouse
- Episode 142: Leah Remini, Adam Brody, Mavis Staples
- Episode 143: Jarod Miller, Kiefer Sutherland, Macy Gray feat. Natalie Cole
- Episode 144: Conan O'Brien, Venus Ramey, Kings of Leon
- Episode 145: Eric Bana, Oscar De La Hoya, Kaiser Chiefs
- Episode 146: Dr. Phil McGraw, Rove McManus, Patti Smith
- Episode 147: Mitt Romney, D.L. Hughley, Fall Out Boy
- Episode 148: Howie Mandel, Bryce Howard, Alan Jackson
- Episode 149: Thomas Haden Church, 102-year-old golfer Elsie McLean, Ne-Yo
- Episode 150: Mike Myers, Floyd Mayweather, The Cat Empire
- Episode 151: Matthew Fox, Larry the Cable Guy, Feist
- Episode 152: Antonio Banderas, Brady Barr, Aqualung
- Episode 153: Cameron Diaz, 6-year-old piano prodigy Ethan Bortnick, Nelly Furtado
- Episode 154: Amazing Animals With Julie Scardina, Gov. Bill Richardson, Miranda Lambert
- Episode 155: Dominic Monaghan, "American Idol" finalists Melinda Doolittle, Blake Lewis & Jordin Sparks, Taylor Hicks
- Episode 156: Orlando Bloom, Maria Lark, Gym Class Heroes
- Episode 157: Ricki Lake, baker Marjorie Johnson, Gretchen Wilson
- Episode 158: Felicity Huffman, bizarre food expert Andrew Zimmern, Dolores O'Riordan
- Episode 159: Jamie Foxx, Jimmy Fallon, Peter Bjorn And John
- Episode 160: Simon Cowell, 95-year-old college graduate Nola Ochs, Maroon 5
- Episode 161: Demi Moore, Judd Apatow, Angelique Kidjo feat. Ziggy Marley
- Episode 162: Gov. Arnold Schwarzenegger, Debra Messing, Fiction Plane
- Episode 163: Kevin Costner, "American Idol" winner Jordin Sparks, Daniel Tosh
- Episode 164: Dennis Miller, Ross "The Intern" Mathews, Dwight Yoakam
- Episode 165: Jessica Alba, Seth Rogen, Lucinda Williams
- Episode 166: George Clooney, senior-citizen band the Zimmers, Rihanna
- Episode 167: Bernie Mac, Cat Deeley, Chris Cornell
- Episode 168: Don Rickles, Josh Flitter, Dashboard Confessional
- Episode 169: Steve Carell, Kenny Smith, The Goo Goo Dolls
- Episode 170: Wanda Sykes, Mathias Sisters, John Mayer
- Episode 171: Fred Thompson, Lauren Graham, Toby Keith
- Episode 172: Terry Bradshaw, Shia LaBeouf, James Morrison
- Episode 173: Téa Leoni, Joy Behar, Bloc Party
- Episode 174: Bill Cosby, Charlie Gilpin, Aspen Nelson & Bryant Ashton, Avril Lavigne
- Episode 175: Robin Williams, Chelsea Handler, Big & Rich
- Episode 176: Michael Chiklis, Bruce Bowen, Sugarland
- Episode 177: Samuel L. Jackson, 17-year-old reptile expert Corbin Maxey, Jesse Malin
- Episode 178: John Cusack, Tavis Smiley, Lifehouse
- Episode 179: Cedric the Entertainer, Chip Foose, Kelly Clarkson
- Episode 180: John & Elizabeth Edwards, Maz Jobrani, The Red Jumpsuit Apparatus
- Episode 181: Michael Moore, Justin Long, Mandy Moore
- Episode 182: Josh Duhamel, David Willey, Jason Aldean
- Episode 183: Dr. Phil McGraw, Leslie Mann, Velvet Revolver
- Episode 184: Ethan Hawke, Carlos Mencia, Breaking Benjamin
- Episode 185: Daniel Radcliffe, Patton Oswalt, The Decemberists
- Episode 186: Adam Sandler, Nikki Blonsky, Silverchair
- Episode 187: John Travolta, Tony Dungy, The Neville Brothers
- Episode 188: Jessica Biel, Bill Engvall, T-Pain feat. Yung Joc
- Episode 190: Bill Maher, Minnie Driver
- Episode 191: Holly Hunter, Kent Couch, Ryan Adams & The Cardinals
- Episode 192: Sandra Bullock, Chris Matthews, Suzanne Vega
- Episode 193: Don Cheadle, Miley Cyrus, Puddle of Mudd
- Episode 194: Glenn Close, Sebastian Manisalco, Marilyn Manson
- Episode 195: Amazing Animals With Julie Scardina, Aaron Eckhart, Common
- Episode 196: Rob Schneider as Lindsay Lohan, Rove McManus, Sum 41
- Episode 197: Matt Damon, George Foreman, Stephen Stills
- Episode 198: Michael Moore, Orny Adams, Perry Farrell's Satellite Party
- Episode 199: Kevin James, Arctic swimmer Lewis Pugh, Katharine McPhee
- Episode 200: Jennifer Lopez, Kevin Nealon, Glen Hansard & Markéta Irglová
- Episode 201: Chris Tucker, Marc Anthony, The John Butler Trio
- Episode 202: Heidi Klum, Anderson Cooper, Brad Paisley
- Episode 203: Claire Danes, Bob Saget, Grace Potter & The Nocturnals
- Episode 204: Hank Azaria, David Hasselhoff, Sharon Osbourne & Piers Morgan, Daddy Yankee
- Episode 205: Michelle Pfeiffer, Jonah Hill, MIMS
- Episode 206: Cuba Gooding Jr., Zac Efron, John McLaughlin
- Episode 207: Seth Rogen, animal trainer Jules Sylvester, Hot Hot Heat
- Episode 208: David Duchovny, Tiki Barber, Nick Thune
- Episode 209: Rainn Wilson, Gordon Ramsay, Fuel
- Episode 210: Drew Carey, Richard Roeper, Colbie Caillat
- Episode 211: Sen. John McCain, Bill Hader, Ben Harper and the Innocent Criminals
- Episode 212: Jeff Foxworthy, Maria Lark, Mat Kearney
- Episode 213: Jonah Hill, Michael Cera, Christopher Mintz-Plasse, Jarod Miller, Wilco
- Episode 214: Seth Green, Mike Rowe, Collective Soul
- Episode 215: Dennis Miller, Capt. Ed Kiesel, Rodrigo Y Gabriela
- Episode 216: Fred Thompson, Jerome Bettis, Travis Tritt
- Episode 217: Daniel Radcliffe, Mark Cuban, Kings of Leon
- Episode 218: Show# 3431
- Episode 219: Brad Garrett, Funny Car racer Ashley Force, Cirque du Soleil
- Episode 220: Denis Leary, Robert Klein, Spoon
- Episode 221: Kelsey Grammer, Dan Fogler, The Bravery
- Episode 222: Terry Bradshaw, Vanessa Hudgens, Michael Buble
- Episode 223: Michael Douglas, Tavis Smiley, Good Charlotte
The Tonight Show with Jay Leno Season 15 Penelope Cruz, John Stamos, "Weird Al" Yankovic
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